Ligand-Selective Interdomain Conformations of Estrogen Receptor-α
نویسندگان
چکیده
منابع مشابه
Antagonists Selective for Estrogen Receptor α.
To develop compounds that are antagonists on ER , but not ER , we have added basic side-chains typically found in nonsteroidal antiestrogens to pyrazole compounds that bind with much higher affinity to ER than to ER . In this way we have developed basic side-chain pyrazoles (BSC-pyrazoles) that are high affinity, potent, selective antagonists on ER . These BSCpyrazoles are themselves inactive o...
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Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target tissue. After tamoxifen, raloxifene, lasofoxifene and bazedoxifene SERMs have been developed and used for treatment. The clinically decisive differ...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2007
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2006-0075